Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	1648	0.0	1.0	0.127	0.214
biological_process	el	1648	0.0	1.0	0.598	0.268
biological_process	ka	1648	0.0	1.0	0.121	0.213
biological_process	rf	1648	0.0	1.0	0.127	0.214
cellular_component	ct	1649	0.0	0.983	0.239	0.27
cellular_component	el	1649	0.0	1.0	0.529	0.286
cellular_component	ka	1649	0.0	0.993	0.243	0.269
cellular_component	rf	1649	0.0	0.983	0.239	0.27
disease	ct	1462	0.0	1.0	0.045	0.143
disease	el	1462	0.0	0.999	0.169	0.225
disease	ka	1462	0.0	1.0	0.044	0.145
disease	rf	1462	0.0	0.999	0.045	0.143
genetic_interaction_unweighted	ct	1606	0.0	1.0	0.418	0.327
genetic_interaction_unweighted	el	1606	0.0	1.0	0.431	0.324
genetic_interaction_unweighted	ka	1606	0.0	1.0	0.843	0.357
genetic_interaction_unweighted	rf	1606	0.0	1.0	0.425	0.33
genetic_interaction_weighted	ct	1606	0.0	1.0	0.417	0.327
genetic_interaction_weighted	el	1606	0.0	1.0	0.436	0.32
genetic_interaction_weighted	ka	1606	0.0	1.0	0.84	0.364
genetic_interaction_weighted	rf	1606	0.0	1.0	0.424	0.329
molecular_function	ct	1634	0.0	0.997	0.33	0.304
molecular_function	el	1634	0.003	0.998	0.502	0.297
molecular_function	ka	1634	0.0	1.0	0.35	0.292
molecular_function	rf	1634	0.0	0.997	0.331	0.304
pathway	ct	653	0.001	1.0	0.29	0.333
pathway	el	653	0.001	1.0	0.339	0.41
pathway	ka	653	0.001	1.0	0.543	0.492
pathway	rf	653	0.001	1.0	0.332	0.41
phenotype	ct	1480	0.0	0.998	0.079	0.17
phenotype	el	1480	0.0	0.998	0.281	0.213
phenotype	ka	1480	0.0	1.0	0.079	0.177
phenotype	rf	1480	0.0	0.998	0.079	0.17
protein_interaction_unweighted	ct	1657	0.0	1.0	0.07	0.163
protein_interaction_unweighted	el	1657	0.0	0.933	0.065	0.157
protein_interaction_unweighted	ka	1657	0.0	1.0	0.304	0.455
protein_interaction_unweighted	rf	1657	0.0	0.926	0.066	0.154
protein_interaction_weighted	ct	1657	0.0	1.0	0.071	0.164
protein_interaction_weighted	el	1657	0.0	0.945	0.438	0.261
protein_interaction_weighted	ka	1657	0.0	1.0	0.302	0.456
protein_interaction_weighted	rf	1657	0.0	0.931	0.069	0.159

Table 2. Backup position values for every kernel after integration

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels